ODCs

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3 OMIM references -
2 associated genes
16 signs/symptoms

PROTEIN INTERACTIONS: 1
COMMON SIGNS: 2

1 OMIM reference -
1 associated gene
12 signs/symptoms

Li-Fraumeni syndrome

Alpha-thalassemia - myelodysplastic syndrome

CHEK2	(UniProt - OMIM)		ATRX	(UniProt - OMIM)
TP53	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	TP53	(0.63)	ATRX

Citations in the biomedical literature:

Li-Fraumeni syndrome		Alpha-thalassemia - myelodysplastic syndrome
	Synonym(s): (no synonyms)		Synonym(s): - ATMDS - Acquired HbH disease - Acquired hemoglobin H disease

	Classification (Orphanet): - Rare endocrine disease - Rare genetic disease - Rare neurologic disease - Rare oncologic disease		Classification (Orphanet): - Rare genetic disease - Rare hematologic disease

	Classification (ICD10): - Neoplasms -		Classification (ICD10): - Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism -

	Epidemiological data: Class of prevalence: unknown Average age onset: adulthood Average age of death: - Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: adulthood Average age of death: elderly Type of inheritance: sporadic

	External references: 3 OMIM references - 1 MeSH reference: D016864		External references: 1 OMIM reference - No MeSH references


COMMON SIGNS	- Acute leukemia - Neoplasms / tumors

Li-Fraumeni syndrome		Alpha-thalassemia - myelodysplastic syndrome
	Very frequent - Autosomal dominant inheritance - Bone / osseous neoplasm / tumor / carcinoma / cancer - Breast neoplasm / tumor / carcinoma / cancer - Central nervous system / peripheral nerves neoplasm / tumor / carcinoma / cancer - Colon neoplasm / tumor / carcinoma / cancer - Cortical adrenal neoplasm / tumor / carcinoma / cancer - Lymphoma - Pancreatic / pancreas neoplasm / tumor / carcinoma / cancer - Sarcoma - Skin / cutaneous neoplasm / tumor / carcinoma / cancer (excluding melanoma) - Soft tissue sarcoma / cancer / tumor / liposarcoma / myosarcoma Occasional - Lung / bronchopulmonary neoplasm / tumor / carcinoma / cancer - Melanoma - Oropharyngeal neoplasm / tumor / carcinoma / cancer		Very frequent - Asthenia / fatigue / weakness - Microcytic anemia - Myelodysplastic syndrome - Polynuclear cells / neutrophils anomalies / neutropenia - Thrombocytopenia / thrombopenia Frequent - Bruisability - Hemorrhage / hemorrhagic syndrome / excessive / long-lasting bleeding - Respiratory distress / dyspnea / respiratory failure / lung volume reduction Occasional - Immunodeficiency / increased susceptibility to infections / recurrent infections - Splenomegaly